Preclinical research
Before the first volunteer is involved, the substance is studied in the lab to see whether it is worth going further at all.
An independent educational reference on how medicines are developed, registered and sold. It is not a pharmacy or manufacturer, sells nothing and has no connection to the former website on this domain; it does not replace a doctor's advice.
Topics
The reference is organised by stages of a medicine's journey, not by disease. First the lab and clinical trials, then the government's registration decision, then the factory, the warehouse and the pharmacy. A separate block covers how patients can avoid sellers who fake that journey.
Each stage answers its own question: does the medicine work, is it safe, was it made and stored correctly. Skip any of them and that question goes unanswered.
How this section works: a topic belongs here if it explains how a medicine travels to the patient and can be covered without naming products, dosing regimens or medical advice. Anything about specific treatment we leave to the doctor.
The road from idea to registration is long, and each step has its own job.
Before the first volunteer is involved, the substance is studied in the lab to see whether it is worth going further at all.
First a small group and the question of safety, then effectiveness, then large comparative studies.
Study does not end at market launch: information about a medicine keeps being collected after registration.
A government allows a medicine onto the market only after reviewing its documents and trial results.
Russia's State Register of Medicines (GRLS) is kept by the Ministry of Health; it shows whether a medicine is registered in Russia. Other countries keep their own registers.
What information usually appears on the package and in the leaflet, and why it is worth reading together with your doctor's prescription.
In Russia, Roszdravnadzor oversees the circulation of medicines and the work of pharmacies; its registers are open to everyone.
One active substance can be made by different companies under different brand names.
A generic contains the same active substance as the originator medicine.
A generic's equivalence to the originator is checked in bioequivalence studies.
Do not swap one medicine for another on a friend's advice; that is a question for your doctor.
The last stretch of the journey — from warehouse to patient — is the one most often faked.
In Russia, only pharmacies with a licence and the corresponding permit may sell medicines at a distance.
WHO warns about the spread of falsified products, especially through unverified online sources.
How not to let a loud headline about a new medicine send you looking for it from a random seller.
This is where standalone articles written for English-language readers will appear: explainers on the stages of drug development, how to approach your country's official medicines information, and practical guides to buying medicines safely.
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How development, registration and oversight, manufacturing and storage of medicines work — without names or regimens.
How to avoid fakes: checking a pharmacy, warning signs and habits that protect you from falsified medicines.
How to read news about a "new drug" and about clinical trials without mistaking a headline for a conclusion.
Information is current as of the preparation date. Rules for registering medicines and selling them at a distance change from time to time, so check the official registers — in Russia, those of the Ministry of Health and Roszdravnadzor; elsewhere, your national medicines regulator — and ask a doctor or pharmacist about treatment.